Q01 Prof. Dr. Boor/Prof. Dr. Longerich/ Dr. Franklin
Histopathologische Analyse und Quantifizierung der Leber- und Nierenfibrose
Die Q1 Platform bietet allen Forschern des SFB/TRR 57 eine hoch-professionelle, standardisierte und reproduzierbare histopathologische Analyse der Leber- und Nierenschädigung und Fibrose. [...]
Die Q1 Platform bietet allen Forschern des SFB/TRR 57 eine hoch-professionelle, standardisierte und reproduzierbare histopathologische Analyse der Leber- und Nierenschädigung und Fibrose. Wir führen semiquantitative Analysen von histopathologischen Organschäden mittels reproduzierbarer Scoringsysteme durch, die teilweise für die menschliche Pathologie etabliert sind. Dies wird für eine Vielzahl von Tiermodellen der Leber- oder Nierenschädigung, die die Forscher innerhalb des Konsortiums verwenden, angepasst angewandt. Wir unterstützen und erzeugen Hypothesen basierend auf spezifischen histopathologischen Befunden. Eine weitere Kernfunktion von Q1 ist die Etablierung und Optimierung von immunhistochemischen und immunfluoreszenz Protokollen für eine Vielzahl von Markern, die für die Forscher innerhalb des Konsortiums interessant sind. Die Q1 Plattform verwendet digitale Pathologie, um computergestützte morphometrische Quantifizierungen und Analysen von Gewebeschädigung und Fibrose durchzuführen und die Kommunikation zwischen Kooperationspartnern aus Aachen und Bonn zu erleichtern. Wir führen auch ultrastrukturelle Analysen mit Hilfe von Elektronenmikroskopie durch. Weiterhin unterstützen wir die Gruppen bei der Vorbereitung von repräsentativen, relevanten und qualitativ hochwertigen histopathologischen Bildern für Veröffentlichungszwecke.
Publikationen
- Kuppe C. , Ibrahim M. M., Kranz J., Zhang X., Ziegler S., Perales-Patón J., Jansen J., Reimer K. C., Smith J. R., Dobie R., Wilson-Kanamori J. R., Halder M., Xu Y., Kabgani N., Kaesler N., Klaus M., Gernhold L., Puelles V. G., Huber T. B., Boor P., Menzel S., Hoogenboezem R. M., Bindels E. M. J., Steffens J., Floege J., Schneider R. K., Saez-Rodriguez J., Henderson N. C., Kramann R. (2020): Decoding myofibroblast origins in human kidney fibrosis. nature, 589, 281–286,
- Klinkhammer B. M. , Djudjaj S., Kunter U., Palsson R., Edvardsson V. O., Wiech T., Thorsteinsdottir M., Hardarson S., Foresto-Neto O., Mulay S. R., Moeller M. J., Jahnen-Dechent W., Floege J., Anders H.J., Boor P. (2020): Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy. Journal of American Society of Nephrology, 31(4), 799-816, [8.491]
- Baues M. , Klinkhammer B. M., Ehling J., Gremse F., van Zandvoort M. A. M. J., Reutelingsperger C. P. M., Daniel C., Amann K., Bábíčková J., Kiessling F., Floege J., Lammers T., Boor P. (2020): A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo. Kidney International, 97(3), 609-614, [8.306]
- Echle A. , Grabsch H. I., Quirke P., van den Brandt P. A., West N. P., Hutchins G. G. A., Heij L. R., Tan X., Richman S. D., Krause J., Alwers E., Jenniskens J., Offermans K., Gray R., Brenner H., Chang-Claude J., Trautwein C., Pearson A. T., Boor P., Luedde T., Gaisa N. T., Hoffmeister M., Kather J. N. (2020): Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. Gastroenterology, 159, 1406-1416,
- Hermert D. , Martin I. V., Reiss L. K., Liu X., Breitkopf D. M., Reimer K. C., Alidousty C., Rauen T., Floege J., Ostendorf T., Weiskirchen R., Raffetseder U. (2020): The nucleic acid binding protein YB-1-controlled expression of CXCL-1 modulates kidney damage in liver fibrosis. Kidney International, 97(4), 741-752, [8.306]
- Weiskirchen R. , Tacke F. (2019): Pathophysiologie: Immunologie.“ Nichtalkoholische Fettleber. (Eds. Andreas Geier, Ali Canbay & Frank Lammert). Springer Verlag, im Druck, [0.200]
- Weiskirchen R. , Tacke F. (2019): Hepatic Fibrogenesis. Reference Module in Biomedical Sciences, , 1-7, [0.200]
- Weiskirchen R. , Tacke F. (2019): Hepatic fibrogenesis. Encyclopedia of Gastroenterology, 2nd Edition, Elsevier, New York, [0.200]
- Weiskirchen R. , Tacke F. (2019): Relevance of autophagy in parenchymal and non-parenchymal liver cells for health and disease. Cells, 8, 16, [5.656]
- van Roeyen C. R. C. , Martin I. V., Drescher A., Schuett K. A., Hermert D., Raffetseder U., Otten S., Buhl E. M., Braun G., Kuppe C., Liehn E., Boor P., Weiskirchen R., Eriksson U., Gross O., Eitner F., Floege J., Ostendorf T. (2019): Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension. Kidney Int, 95, 1103-1119, [8.000]
- Sun Q. , Baues M., Klinkhammer B. M., Ehling J., Djudjaj S., Drude N. I., Daniel C., Amann K., Kramann R., Kim H., Saez-Rodriguez J., Weiskirchen R., Onthank D. C., Botnar R. M., Kiessling F., Floege J., Lammers T., Boor P. (2019): Elastin imaging enables non-invasive staging and treatment monitoring of kidney fibrosis. Sci Transl Med, 11, 486, [17.161]
- Puelles V. G. , Fleck D., Ortz L., Papadouri S., Strieder T., Boehner A., van der Wolde J. W., Vogt M., Saritas T., Kuppe C., Fuss A., Menzel S., Klinkhammer B. M., Müller-Newen G., Heymann F., Decker L., Braun F., Kretz O., Huber T. B., Susaki E. A., Ueda H. R., Boor P., Floege J., Kramann R., Kurts C., Bertram J. F., Spehr M., Nikolic-Paterson D. J., Moeller M. J. (2019): 3D analysis of rapidly progressive glomerulonephritis using optical tissue clearing. Kidney Int, 96, 505-516, [8.306]
- Poluzzi C. , Nastase M. V., Zeng-Brouwers J., Roedig H., Hsieh L. T. H., Michaelis J. B., Abderrahman N. B., Buhl E. M., Rezende F., Manavski Y., Bleich A., Boor P., Brandes R. P., Pfeilschifter J., Stelzer E. H. K., Münch C., Dikic I., Brandts C., Iozzo R. V., Wygrecka M. Schaefer L. (2019): Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis: Impact on renal ischemia/reperfusion injury. Kidney Int, 95, 540-562, [8.429]
- Mulay S. R. , Honarpisheh M. M., Foresto-Neto O., Shi C., Desai J., Zhao Z. B., Marschner J. A., Popper B., Buhl E. M., Boor P., Linkermann A., Liapis H., Bilyy R., Herrmann M., Romagnani P., Belevich I., Jokitalo E., Becker J. U., Anders H. J. (2019): Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI. Am Soc Nephrol., 30, 1857-1869, [8.547]
- Kuppe C. , Leuchtle K., Wagner A., Kabgani N., Saritas T., Puelles V. G., Smeets B., Hakroush S., van der Vlag J., Buhl E. M., Boor P., Schiffer M., Gröne H. J., Fogo A., Floege J., Moeller M. J. (2019): Novel parietal epithelial cell subpopulations in FSGS and the origin of the glomerular tip lesion. Kidney Int, 96, 80-93, [8.306]
- Klein S. , Frohn F., Magdaleno F., Reker-Smit C., Schierwagen R., Schierwagen I., Uschner F. E., Fürst D. O., Djudjaj S., Boor P., Poelstra K., Beljaars L., Trebicka J. (2019): Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces fibrogenesis and portal pressure in cirrhotic rats with increased renal perfusion. Sci Rep, 9, 2256, [4.011]
- Kather J. N. , Pearson A. T., Halama N., Jäger D., Krause J., Loosen S. H., Marx A., Boor P., Tacke F., Neumann U. P., Grabsch H. I., Yoshikawa T., Brenner H. B., Chang-Claude J., Hoffmeister M., Trautwein C., Luedde T. (2019): Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med, 25, 1054-1056, [30.641]
- Gadermayr M. , Gupta L., Appel V., Boor P., Klinkhammer B. M., Merhof D. (2019): Generative Adversarial Networks for Facilitating Stain-Independent Supervised & Unsupervised Segmentation: A Study on Kidney Histology. IEEE Trans Med Imaging (TMI), 38, 2293-2302, [7.816]
- Stoppe C. , Averdunk L., Goetzenich A., Soppert J., Marlier A., Kraemer S., Vieten J., Coburn M., Stevanovic A., Kim B.-S., Marx G., Rex S., Ochi A., Leng L., Moeckel G., Linkermann A., El Bounkari O., Zarbock A., Bernhagen J., Djudjaj S., Bucala R., Boor P. (2018): The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery. Sci Transl Med, 10, 4886, [23.401]
- Rolfes V. , Idel C., Pries R., Plötze-Martin K., Habermann J., Gemoll T., Bohnet S., Latz E., Ribbat-Idel J., Franklin B. S., Wollenberg B. (2018): PD-L1 is expressed on human platelets and is affected by immune checkpoint therapy. Oncotarget, 9, 27460-27470, [5.168]
- Müller S. , Djudjaj S., Lange J., Iacovescu M., Goppelt-Struebe M., Boor P. (2018): HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations. Sci Rep, 8, 9497, [4.011]
- Moellmann J. , Klinkhammer B. M., Onstein J., Stöhr R., Jankowski V., Jankowski J., Lebherz C., Tacke F., Marx N., Boor P., Lehrke M. (2018): Glucagon-like peptide-1 and its cleavage products are renoprotective in murine diabetic nephropathy. Diabetes, 67(11), 2410-2419, [7.199]
- Martin I. V. , Bohner A., Boor P., Shagdarsuren E., Raffetseder U., Lammert F., Floege J., Ostendorf T., Weber S. N. (2018): Complement C5a receptors C5L2 and C5aR in renal fibrosis. Am J Physiol Renal Physiol, 314, F35-F46, [3.611]
- Gross A. , Pack L. A. P., Schacht G. M., Kant S., Ungewiss S., Meir M., Schlegel N., Preisinger C., Boor P., Güldiken N., Krusche C. A., Sellge G., Trautwein C., Waschke J., Heuser A., Leube R. E., Strnad P. (2018): Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury. Mucosal Immunol, 11, 1630-1639, [7.352]
- Gibbert L. , Hermert D., Wang J., Breitkopf D. M., Alidousty C., Neusser M., Cohen C. D., Gröne E., Macheleidt I., Rauen T., Braun G. S., Floege J., Ostendorf T., Raffetseder U. (2018): YB-1 increases glomerular, but decreases interstitial fibrosis in CNI-induced nephropathy. Clin Immunol, 194, 67-74, [3.557]
- Gadermayr M. , Dombrowski A.-K., Klinkhammer B. M., Boor P., Merhof D. (2018): CNN Cascades for Segmenting Sparse Objects in Gigapixel Whole Slide Images. Comput Med Imaging Graph, 71, 40-48, [3.298]
- Franklin B. S. , Mangan M. S., Latz E. (2018): Crystal Formation in Inflammation. Annual Reviews of Immunology, 34, 173-202, [21.429]
- Buchtler S. , Grill A., Hofmarksrichter S., Stöckert P., Schiechl-Brachner G., Rodriguez Gomez M., Neumayer S., Schmidbauer K., Talke Y., Klinkhammer B. M., Boor P., Medvinsky A., Renner K., Castrop H., Mack M. (2018): Cellular Origin and Functional Relevance of Collagen I Production in the Kidney. J Am Soc Nephrol, 29(7), 1859-1873, [8.547]
- Martin, I.V. , Bohner, A., Boor, P., Shagdarsuren, E., Raffetseder, U., Lammert, F., Floege, J., Ostendorf, T., Weber, S.N. (2017): Complement C5a receptors C5L2 and C5aR in renal fibrosis. American Journal of Physiology, 314 (1), 35-46, [27.312]
- Djudjaj, S. , Martin, I.V., Buhl, E.M., Nothofer, N.J., Leng, L., Piecychna, M., Floege, J., Bernhagen, J., Bucala, R., Boor, P. (2017): Macrophage Migration Inhibitory Factor limits renal Inflammation and fibrosis by counteracting tubular cell cycle arrest. Journal of the American Society of Nephrology, 28 (12), [8.491]
- Wang, J. , Djudjaj, S., Gibbert, L., Lennartz, V., Breitkopf, D., Rauen, T., Hermert, D., Martin, I.V., Boor, P., Braun, G.S., Floege, J., Ostendorf, T., Raffetseder, U. (2017): YB-1 mediates both, onset an resolution of inflammation. Journal of Cellular and Molecular Medicine, [5.090]
- Klinkhammer B.M. , Goldschmeding R., Floege J., Boor P. (2017): Treatment of Renal Fibrosis – turning challenges into opportunities. Advances in Chronic Kidney Disease, 24(2),, 117–129, [2.703]
- Bábíčková J. , Klinkhammer B.M., Buhl E.M., Djudjaj S., Hoss M., Heymann F., Tacke F., Floege J., Becker J.U., Boor P. (2017): Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries. Kidney International, 91(1), 70-85, [7.683]
- Heier E.C. , Meier A., Julich-Haertel H., Djudjaj S., Rau M., Tschernig T., Geier A., Boor P., Lammert F., Lukacs-Kornek V. (2017): CD103+ dendritic cells protect against steatosis progression towards steatohepatitis. Journal of Hepathology, 66(6), 1241-1250, [10.590]
- Wang J. , Gibbert L., Djudjaj S., Alidousty C., Rauen T., Kunter U., Rembiak A., Enders D., Jankowski V., Braun G. S., Floege J., Ostendorf T., Raffetseder U. (2016): Therapeutic nuclear shuttling of YB-1 reduces renal damage and fibrosis. Kidney Int, 90, 1226-1237, [8.395]
- Wang J. , Gibbert L., Djudjaj S., Alidousty C., Rauen T., Kunter U., Rembiak A., Enders D., Jankowski V., Braun G. S., Floege J., Ostendorf T., Raffetseder U. (2016): Therapeutic nuclear shuttling of YB-1 reduces renal damage and fibrosis. Kidney Int, 90, 1226-1237, [8.395]
- Buhl, E. M. , Djudjaj, S., Babickova, J., Klinkhammer, B. M., Folestad, E., Borkham-Kamphorst, E., Weiskirchen, R., Hudkins, K., Alpers, C. E., Eriksson, U., Floege, J., Boor, P. (2016): Role of PDGF-D in healthy and fibrotic kidneys.. Kidney Int, 89, 848-861, [7.683]
- Toivola, D. M. , Boor, P., Alam, C., Strnad, P. (2015): Keratins in health and disease.. Current Opinion in Cell Biology, 32, 73-81, [8.851]
- Schierwagen, R. , Maybüchen, L., Zimmer, S., Hittatiya, K., Bäck, C., Klein, S., Uschner, F. E., Reul, W., Boor, P., Nickenig, G., Strassburg, C. P., Trautwein, C., Plat, J., Lütjohann, D., Sauerbruch, J. (2015): Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis. Sci Rep, Aug 11;5, 12931, [5.580]
- Papasotiriou, M. , Genovese, F., Klinkhammer, B. M., Kunter, U., Nielsen, S. H., Karsdal, M. A., Floege, J., Boor, P. (2015): Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases.. Nephrol Dial Transplant, 30, 1112-1121, [4.085]
- Kalenski, J. , ., Mancina, E., Paschenda, P., Beckers, C., Bleilevens, C., Tóthová, L'., Boor, P., Doorschodt, B. M., Tolba, R.H. (2015): Improved Preservation of Warm Ischemia Damaged Porcine Kidneys after Cold Storage in Ecosol, a Novel Preservation Solution.. Annals of Transplantation, 20, 233-242, [1.032]
- Kuppe, C. , Gröne, H. J., Ostendorf, T., van Kuppevelt, T. H., Boor, P., Floege, J., Smeets, B., Moeller, M. J. (2015): Common histological patterns in glomerular epithelial cells in secondary focal segmental glomerulosclerosis.. Kidney Intdoi, 10.1038, ki.2015.116, [7.683]
- Engel, D. R. , Krause, T., Snelgrove, S., Thiebes, S., Boor, P., Kitching, R., Kurts, C. (2015): (2015): CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages.. J Immunol, 194, 1628-1638, [4.920]
- Genovese, F. , Boor, Ü., Üaüasotiriou, M., Leeming, D. J., Karsdal, M. A., Floege, J. (2015): Turnover of type III collagen reflects disease severity and is associated with progression and microinflammation in patients with IgA nephropathy.. Nephrol Dial Transplant, pii, gfv, 301, [3.580]
- Djudjaj, S , Lue, H. J., Rong, S., Papasotiriou, M., Klinkhammer, B. M., Zok, S., Klaener, O., Braun, G. S., Lindenmeyer, M. T., Cohen, C. D., Bucala, R., Tittel, A. P., Kurts, C., Moeller, M. J., Floege, J., Boor, P. (2015): Macrophage migration inhibitory factor mediates proliferative glomerulonephritis via CD74.. J Am Soc Nephrol, , in press, [9.340]
- Ehling, J. , Bábíčková , J., Gremse, F., Klinkhammer, B. M., Baetke, S. H., Knuechel, R., Kiessling, F., Floege, J., Lammers, T., Boor, P. (2015): Quantitative micro-CT imaging of micro-to-macrovascular dysfunction in progressive kidney diseases.. J Am Soc Nephrol, ASN.2015020204, [9.340]
- Boor, P. , Floege, J. (2015): Renal Allograft Fibrosis: Biology and Therapeutic Targets.. Am J Transplant, 15, 863-886, [5.680]
- Boor, P. , Bábíčková, J., Steegh, F., Hautvast, P., Martin, I. V., Djudjaj, S., Nakagawa, T., Ehling, J., Gremse, F., Bücher, E., Eriksson, U., van Roeyen, C. R. C., Eitner, F., Lammers, T., Floege, T. (2015): Role of PDGF-CC in capillary rarefaction in renal fibrosis.. Am J Pathol, 185, 2132-2142, [4.590]
- Boor, P. , Papasptiriou, M. E. (2015): If you lose your nerves, at least you will not get kidney fibrosis!. Kidney Int, 87(2), 275-277, [8.560]
- Boor, P , Perkuhn, M., Weibrecht, M., Zok, S., Martin, I. V., Gieseke, J., Schoth, F., Ostendorf, T., Kuhl, C., Floege, J. (2015): Diffusion-weighted MR imaging does not reflect kidney fibrosis in rat model of fibrosis.. JMRI, 1002/jmri, 24853, [2.510]
- Trebicka, J. , Wix, C., von Heydebrand, M., Hittatiya, K., Reiberger, T., Klein, S., Schierwagen, R., Kristiansen, G., Peck-Radosavljevic, M., Fischer, H. P., Møller , S., Bendtsen, F., Krag, A., Sauerbruch, T. (2015): Expression of vasoactive proteins in gastric antral mucosa reflects vascular dysfunction in patients with cirrhosis and portal hypertension.. Liver International, 35(4), 1993-1402, [4.470]
- Lunova, M. , Trautwein, C., Nahon, P., Strnad, P. (2015): Hepcidin in chronic liver disease and hepatocellular carcinoma: The plot thickens. J Hepatol, 62, 979-980, [10.590]
- Kukuk, G. M. , Hittatiya, K., Sprinkart, A. M., Eggers, H., Gieseke, J., Block, W., Moeller, P., Willinek, W. A., Spengler, U., Trebicka, J., Fischer, H. P., Schild, H. H., Träber, F. (2015): Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis. Eur Radiol, , [Epub ahead of print], [3.640]
- Jalan, R. , Pavesi, M., Saliba, F., Amorós, A., Fernandez, J., Holland-Fischer, P., Sawhney, R., Mookerjee, R., Caraceni, P., Moreau, R., Caraceni, P., Moreau, R., Ginès, P., Durand, F., Angeli, W., Trebicka, J., Samuel, D., Zeuzem, S., Gustot, T., Gerbes, A. L., Wendon, J., Bernardi, M., Arroyo, V. (2015): The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure.. J Hepatol, 62(4), 831-840, [10.590]
- Eslam, M. , Hashem, A. M., Leung, R., Romero-Gomez, M., Berg, T., Dore, G. J., Chan, H. L., Irving, W. L., Sheridan, D., Abate, M. L., Adams, L. A., Mangia, A., Weltman, M., Burgianesi, E., Spengler, U., Shaker, O., Fischer, J., Mollison, L., Cheng, W., Powell, E., Nattermann, J., Riordan, S., McLeod, D., Armstrong, N. J., Douglas, M. W., Liddle, C., Booth, D. R., George, J., Ahlenstiel, G., International Hepatitis, C. G. C. (2015): Interferon-lambda rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease. Nat Commun, 6, 6422,
- Nagayama, Y. (2014): Gp130-dependent signaling in the podocyte.. American Journal of Physiology Renal Physiology, 307 (3), F346-F355, [3.390]
- Wögenstein, K. L. , Szabo, S., Lunova, M., Wiche, G., Haybaeck, J., Strnad, P., Boor, P., Wagner, M., Fuchs, P. (2014): Epiplakin-deficiecy aggravates caerulein-induced murine pancreatitis by impaired acinar keratin filament reorganization. PLoS One, 18 (9), e108323, [3.057]
- Šebekova, K. , Dušinska, M., Simon Klenovics, K., Kollarova, R., Kebis, A., Staruchova, M., Vlkova, B., Boor, P., Celec, P., Hodosy, J., Beňo, M., Tulinska, J., Pribojova, J., Bilaničova, D., Pojana, G., Marcomini, A., Volkovova, K. (2014): Comprehensive assessment of nephrotoxicity of intravenously administered sodium-oleate-coated ultrasmall superparamagnetic iron oxide (USPIO) and titanium dioxide (TiO2) nanoparticles in rats. Nanotoxicology, 8(2), 142-157, [7.913]
- Schulte, K. , Berger, K., Boor, P., Jirak, P., Gelman, I. H., Arkull, K. P., Neal, C. R., Kriz, W., Floege, J., Smeets, B., Moeller, M. J. (2014): Origin of Parietal Podocytes in Atubular Glomeruli Mapped by Lineage Tracing. Journal of the American Society of Nephrology, 25(1), 129-141, [8.491]
- Ostendorf, T. , Boor, P., van Roeyen, C. R. C., Floege, J. (2014): Platelet Derived Growth Factors (PDGFs) in Glomerular and Tubulointerstitial Fibrosis.. Kidney International Supplements, 4, 65-69, [7.026]
- Kim, S. , Becker, J., Bechheim, M., Kaiser, V., Noursadeghi, M., Fricker, N., Beier, E., Klaschik, S., Boor, P., Hess, T., Hofmann, A., Holdenrieder, S., Wendland, J., Fröhlich, H., Hartmann, G., Nöthen, M., Müller-Myhsok, B., Pütz, B., Hornung, V., Schumacher, J. (2014): Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes. Nature Communications, 5, 5236, [11.329]
- Klinkhammer, B. M. , Kramann R., Mallau M., Makowska A., van Roeyen C.R., Rong S., Buecher E.B.. Boor P., Kovacova K., Zok S., Denecke B., Stuettgen E., Otten S., Floege J., Kunter U. (2014): Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential. PLoS One, 9 (3), e92-115, [3.057]
- Genovese, F. , Manresa, A. A., Leeming, D. J., Karsdal, M. A., Boor, P. (2014): The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?. Fibrogenesis &Tissue Repair, 7(1), 4, [2.329]
- Boor, P. , Ostendorf, T., Floege, J. (2014): PDGF and the progression of renal disease. Nephrology Dialysis Transplantation, 29, 45-54, [4.085]
- Berger, K. , Schulte, K., Boor, P., Kuppe, C., van Kuppevelt, T. H., Floege, J., Smeets, B., Moeller, M. J. (2014): The Regenerative Potential of Parietal Epithelial Cells in Adult Mice.. J Am Soc Nephrol., 25(4), 693-705, [8.491]
- Smeets, B. , Stucker, F., Wetzels, J., Brocherigou, I., Ronco, P., Gröne, H. J., D'Agati, V., Fogo, A., van Kuppevelt, T. H., Fischer, H. P., Boor, P., Floege, J., Ostendorf, T., Moeller, M. J. (2014): Detection of activated parietal epithelial cells on the glomerular tuft distinguishes early focal segmental glomerulosclerosis from minimal change disease. The American Journal of Pathology, 184, 3240-3248, [4.206]
- Nischalke, H.D. , Lutz P, Krämer B, Söhne J, Müller T, Rosendahl J, Fischer J, Berg T, Hittatiya K, Fischer HP, Soyka M, Semmo N, Nattermann J, Sauerbruch T, Strassburg CP, Stickel F, Spengler U. (2014): A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease.. Journal of Hepatology, 61 (5), 1073-1079, [10.590]
- Seikrit, C. , Henkel C, van Roeyen CRC, Bokemeyer D, Eitner F, Martin IV, Boor P, Ruth Knüchel, Meyer HE, Müller-Newen G, Eriksson U, Floege J, Ostendorf T. (2013): Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts. Nephrol Dial Transplant, Apr;28(4), 889-900, [4.085]
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