P25 Prof. Dr. Boor/Prof. Dr. Floege
Cell-specific role of the PDGF system in renal fibrosis

We aim to analyse the role of PDGF-BB, the ligand of both PDGF receptor chains α and β, in progressive kidney diseases using genetic deletion of PDGF-B in a cell-specific manner. We also aim to clarify the role of PDGFR signaling in the perivascular Gli1+ precursors of renal, but also liver myofibroblasts using mice with inducible activation of constitutively active PDGFR mutants specifically in Gli1+ cells. Finally, we aim to evaluate the components of the PDGF system as potential biomarkers or molecular imaging modalities for the non-invasive assessment of renal fibrosis. [...]

Publications

• Kuppe C. , Ibrahim M. M., Kranz J., Zhang X., Ziegler S., Perales-Patón J., Jansen J., Reimer K. C., Smith J. R., Dobie R., Wilson-Kanamori J. R., Halder M., Xu Y., Kabgani N., Kaesler N., Klaus M., Gernhold L., Puelles V. G., Huber T. B., Boor P., Menzel S., Hoogenboezem R. M., Bindels E. M. J., Steffens J., Floege J., Schneider R. K., Saez-Rodriguez J., Henderson N. C., Kramann R. (2020): Decoding myofibroblast origins in human kidney fibrosis. nature, 589, 281–286,
• Klinkhammer B. M. , Djudjaj S., Kunter U., Palsson R., Edvardsson V. O., Wiech T., Thorsteinsdottir M., Hardarson S., Foresto-Neto O., Mulay S. R., Moeller M. J., Jahnen-Dechent W., Floege J., Anders H.J., Boor P. (2020): Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy. Journal of American Society of Nephrology, 31(4), 799-816, [8.491]
• Baues M. , Klinkhammer B. M., Ehling J., Gremse F., van Zandvoort M. A. M. J., Reutelingsperger C. P. M., Daniel C., Amann K., Bábíčková J., Kiessling F., Floege J., Lammers T., Boor P. (2020): A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo. Kidney International, 97(3), 609-614, [8.306]
• Echle A. , Grabsch H. I., Quirke P., van den Brandt P. A., West N. P., Hutchins G. G. A., Heij L. R., Tan X., Richman S. D., Krause J., Alwers E., Jenniskens J., Offermans K., Gray R., Brenner H., Chang-Claude J., Trautwein C., Pearson A. T., Boor P., Luedde T., Gaisa N. T., Hoffmeister M., Kather J. N. (2020): Clinical-Grade Detection of Microsatellite Instability in Colorectal Tumors by Deep Learning. Gastroenterology, 159, 1406-1416,
• Hermert D. , Martin I. V., Reiss L. K., Liu X., Breitkopf D. M., Reimer K. C., Alidousty C., Rauen T., Floege J., Ostendorf T., Weiskirchen R., Raffetseder U. (2020): The nucleic acid binding protein YB-1-controlled expression of CXCL-1 modulates kidney damage in liver fibrosis. Kidney International, 97(4), 741-752, [8.306]
• van Roeyen C. R. C. , Martin I. V., Drescher A., Schuett K. A., Hermert D., Raffetseder U., Otten S., Buhl E. M., Braun G., Kuppe C., Liehn E., Boor P., Weiskirchen R., Eriksson U., Gross O., Eitner F., Floege J., Ostendorf T. (2019): Identification of platelet-derived growth factor C as a mediator of both renal fibrosis and hypertension. Kidney Int, 95, 1103-1119, [8.000]
• Tajti F. , Kuppe C., Antoranz a., Ibrahim M. M., Kim H., Ceccarelli F., Holland C. H., Olauson H., Flege J., Alexopoulos L. G., Kramann R., Saez-Rodriguez J. (2019): A functional landscape of chronic kidney disease entities from public transcriptomic data. Kidney International Reports, [2.260]
• Sun Q. , Baues M., Klinkhammer B. M., Ehling J., Djudjaj S., Drude N. I., Daniel C., Amann K., Kramann R., Kim H., Saez-Rodriguez J., Weiskirchen R., Onthank D. C., Botnar R. M., Kiessling F., Floege J., Lammers T., Boor P. (2019): Elastin imaging enables non-invasive staging and treatment monitoring of kidney fibrosis. Sci Transl Med, 11, 486, [17.161]
• Puelles V. G. , Fleck D., Ortz L., Papadouri S., Strieder T., Boehner A., van der Wolde J. W., Vogt M., Saritas T., Kuppe C., Fuss A., Menzel S., Klinkhammer B. M., Müller-Newen G., Heymann F., Decker L., Braun F., Kretz O., Huber T. B., Susaki E. A., Ueda H. R., Boor P., Floege J., Kramann R., Kurts C., Bertram J. F., Spehr M., Nikolic-Paterson D. J., Moeller M. J. (2019): 3D analysis of rapidly progressive glomerulonephritis using optical tissue clearing. Kidney Int, 96, 505-516, [8.306]
• Poluzzi C. , Nastase M. V., Zeng-Brouwers J., Roedig H., Hsieh L. T. H., Michaelis J. B., Abderrahman N. B., Buhl E. M., Rezende F., Manavski Y., Bleich A., Boor P., Brandes R. P., Pfeilschifter J., Stelzer E. H. K., Münch C., Dikic I., Brandts C., Iozzo R. V., Wygrecka M. Schaefer L. (2019): Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis: Impact on renal ischemia/reperfusion injury. Kidney Int, 95, 540-562, [8.429]
• Mulay S. R. , Honarpisheh M. M., Foresto-Neto O., Shi C., Desai J., Zhao Z. B., Marschner J. A., Popper B., Buhl E. M., Boor P., Linkermann A., Liapis H., Bilyy R., Herrmann M., Romagnani P., Belevich I., Jokitalo E., Becker J. U., Anders H. J. (2019): Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI. Am Soc Nephrol., 30, 1857-1869, [8.547]
• Kuppe C. , Leuchtle K., Wagner A., Kabgani N., Saritas T., Puelles V. G., Smeets B., Hakroush S., van der Vlag J., Buhl E. M., Boor P., Schiffer M., Gröne H. J., Fogo A., Floege J., Moeller M. J. (2019): Novel parietal epithelial cell subpopulations in FSGS and the origin of the glomerular tip lesion. Kidney Int, 96, 80-93, [8.306]
• Klein S. , Frohn F., Magdaleno F., Reker-Smit C., Schierwagen R., Schierwagen I., Uschner F. E., Fürst D. O., Djudjaj S., Boor P., Poelstra K., Beljaars L., Trebicka J. (2019): Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces fibrogenesis and portal pressure in cirrhotic rats with increased renal perfusion. Sci Rep, 9, 2256, [4.011]
• Kather J. N. , Pearson A. T., Halama N., Jäger D., Krause J., Loosen S. H., Marx A., Boor P., Tacke F., Neumann U. P., Grabsch H. I., Yoshikawa T., Brenner H. B., Chang-Claude J., Hoffmeister M., Trautwein C., Luedde T. (2019): Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med, 25, 1054-1056, [30.641]
• Hermert D. , Martin I.V., Reiss L.K., Breitkopf D.M., Rauen T., Floege J., Ostendorf T., Weiskirchen R., Raffetseder U. (2019): YB-1-controlled CXCL-1 expression decides on kidney damage in liver fibrosis. Kidney Int, [8.395]
• Gadermayr M. , Gupta L., Appel V., Boor P., Klinkhammer B. M., Merhof D. (2019): Generative Adversarial Networks for Facilitating Stain-Independent Supervised & Unsupervised Segmentation: A Study on Kidney Histology. IEEE Trans Med Imaging (TMI), 38, 2293-2302, [7.816]
• Breitkopf D. M. , Jankowski V., Ohl K., Hermann J., Hermert D., Tenbrock K., Liu X., Martin I. V., Wang J., Groll F., Gröne E., Floege J., Ostendorf T., Rauen T., Raffetseder U. (2019): The YB-1:Notch-3 axis modulates immune cell responses and organ damage in systemic lupus erythematosus. Kidney Int, in press, [8.306]
• Stoppe C. , Averdunk L., Goetzenich A., Soppert J., Marlier A., Kraemer S., Vieten J., Coburn M., Stevanovic A., Kim B.-S., Marx G., Rex S., Ochi A., Leng L., Moeckel G., Linkermann A., El Bounkari O., Zarbock A., Bernhagen J., Djudjaj S., Bucala R., Boor P. (2018): The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery. Sci Transl Med, 10, 4886, [23.401]
• Müller S. , Djudjaj S., Lange J., Iacovescu M., Goppelt-Struebe M., Boor P. (2018): HIF stabilization inhibits renal epithelial cell migration and is associated with cytoskeletal alterations. Sci Rep, 8, 9497, [4.011]
• Moellmann J. , Klinkhammer B. M., Onstein J., Stöhr R., Jankowski V., Jankowski J., Lebherz C., Tacke F., Marx N., Boor P., Lehrke M. (2018): Glucagon-like peptide-1 and its cleavage products are renoprotective in murine diabetic nephropathy. Diabetes, 67(11), 2410-2419, [7.199]
• Martin I. V. , Bohner A., Boor P., Shagdarsuren E., Raffetseder U., Lammert F., Floege J., Ostendorf T., Weber S. N. (2018): Complement C5a receptors C5L2 and C5aR in renal fibrosis. Am J Physiol Renal Physiol, 314, F35-F46, [3.611]
• Gross A. , Pack L. A. P., Schacht G. M., Kant S., Ungewiss S., Meir M., Schlegel N., Preisinger C., Boor P., Güldiken N., Krusche C. A., Sellge G., Trautwein C., Waschke J., Heuser A., Leube R. E., Strnad P. (2018): Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury. Mucosal Immunol, 11, 1630-1639, [7.352]
• Gibbert L. , Hermert D., Wang J., Breitkopf D. M., Alidousty C., Neusser M., Cohen C. D., Gröne E., Macheleidt I., Rauen T., Braun G. S., Floege J., Ostendorf T., Raffetseder U. (2018): YB-1 increases glomerular, but decreases interstitial fibrosis in CNI-induced nephropathy. Clin Immunol, 194, 67-74, [3.557]
• Gadermayr M. , Dombrowski A.-K., Klinkhammer B. M., Boor P., Merhof D. (2018): CNN Cascades for Segmenting Sparse Objects in Gigapixel Whole Slide Images. Comput Med Imaging Graph, 71, 40-48, [3.298]
• Buchtler S. , Grill A., Hofmarksrichter S., Stöckert P., Schiechl-Brachner G., Rodriguez Gomez M., Neumayer S., Schmidbauer K., Talke Y., Klinkhammer B. M., Boor P., Medvinsky A., Renner K., Castrop H., Mack M. (2018): Cellular Origin and Functional Relevance of Collagen I Production in the Kidney. J Am Soc Nephrol, 29(7), 1859-1873, [8.547]
• Martin, I.V. , Bohner, A., Boor, P., Shagdarsuren, E., Raffetseder, U., Lammert, F., Floege, J., Ostendorf, T., Weber, S.N. (2017): Complement C5a receptors C5L2 and C5aR in renal fibrosis. American Journal of Physiology, 314 (1), 35-46, [27.312]
• Djudjaj, S. , Martin, I.V., Buhl, E.M., Nothofer, N.J., Leng, L., Piecychna, M., Floege, J., Bernhagen, J., Bucala, R., Boor, P. (2017): Macrophage Migration Inhibitory Factor limits renal Inflammation and fibrosis by counteracting tubular cell cycle arrest. Journal of the American Society of Nephrology, 28 (12), [8.491]
• Heier E.C. , Meier A., Julich-Haertel H., Djudjaj S., Rau M., Tschernig T., Geier A., Boor P., Lammert F., Lukacs-Kornek V. (2017): CD103+ dendritic cells protect against steatosis progression towards steatohepatitis. Journal of Hepathology, 66(6), 1241-1250, [10.590]
• Bábíčková J. , Klinkhammer B.M., Buhl E.M., Djudjaj S., Hoss M., Heymann F., Tacke F., Floege J., Becker J.U., Boor P. (2017): Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries. Kidney International, 91(1), 70-85, [7.683]
• Klinkhammer B.M. , Goldschmeding R., Floege J., Boor P. (2017): Treatment of Renal Fibrosis – turning challenges into opportunities. Advances in Chronic Kidney Disease, 24(2),, 117–129, [2.703]
• Wang, J. , Djudjaj, S., Gibbert, L., Lennartz, V., Breitkopf, D., Rauen, T., Hermert, D., Martin, I.V., Boor, P., Braun, G.S., Floege, J., Ostendorf, T., Raffetseder, U. (2017): YB-1 mediates both, onset an resolution of inflammation. Journal of Cellular and Molecular Medicine, [5.090]
• Wang J. , Gibbert L., Djudjaj S., Alidousty C., Rauen T., Kunter U., Rembiak A., Enders D., Jankowski V., Braun G. S., Floege J., Ostendorf T., Raffetseder U. (2016): Therapeutic nuclear shuttling of YB-1 reduces renal damage and fibrosis. Kidney Int, 90, 1226-1237, [8.395]
• Wang J. , Gibbert L., Djudjaj S., Alidousty C., Rauen T., Kunter U., Rembiak A., Enders D., Jankowski V., Braun G. S., Floege J., Ostendorf T., Raffetseder U. (2016): Therapeutic nuclear shuttling of YB-1 reduces renal damage and fibrosis. Kidney Int, 90, 1226-1237, [8.395]
• Ludwig-Portugall I., , Bartok E., Dhana E., Evers B.D.G., Primiano M.J., Hall J.P., Franklin B.S., Knolle P.A., Hornung V., Hartmann G., Boor P, Latz E., Kurts C. (2016): An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice. Kidney International, 90(3), 525–539, [7.683]
• von Stillfried S. , Apitzsch J.C., Ehling J., Penzkofer T., Mahnken A.H., Knüchel R., Floege J., Boor P. (2016): Contrast-enhanced CT imaging in patients with chronic kidney disease. Angiogenesis, 19(4), 525–535, [4.301]
• Guldiken N. , Ensari G.K., Lahiri P., Couchy G., Preisinger C., Liedtke C., Zimmermann H.W., Ziol M., Boor P., Zucman-Rossi J., Trautwein C., Strnad P. (2016): Keratin 23 is a general stress-inducible marker of mouse and human ductular reaction in liver disease. Journal of Hepatology, 65(3), 552–559, [10.590]
• Beyer M. , Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL (2016): Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.. Nat Immunol, May;17(5), 593-603. doi: 10.1038/ni.3399. Epub 2016 Mar 7. PubMed PMID: 26950238,
• Evers B.D.G. , Engel D.R., Böhner A.M.C., Tittel A.P., Krause T.A., Heuser C., Garbi N., Kastenmüller W., Mack M., Tiegs G., Panzer U., Boor P., Ludwig-Portugall I., Kurts C. (2016): CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10–Producing Regulatory T Cells. Journal of the American Society of Nephrology, 27(11), 3368-3382, [8.491]
• Ehling, J. , Bábíčková, J., Gremse, F., Klinkhammer, B. M., Baetke, S. H., Knuechel, R., Kiessling, F., Floege, J., Lammers, T., Boor, P. (2016): Quantitative micro-CT imaging of micro-to-macrovascular dysfunction in progressive kidney diseases. Journal of the American Society of Nephrology], 27(2), 520–532, [8.491]
• Djudjaj, S. , Lue, H. J., Rong, S., Papasotiriou, M., Klinkhammer, B. M., Zok, S., Klaener, O., Braun, G. S., Lindenmeyer, M. T., Cohen, C. D., Bucala, R., Tittel, A. P., Kurts, C., Moeller, M. J., Floege, J., Boor, P. (2016): Macrophage migration inhibitory factor mediates proliferative glomerulonephritis via CD74. Journal of the American Society of Nephrology, 27 (6), 1650-1664, [8.491]
• Djudjaj S. , Papasotiriou M., Bülow R.D., Wagnerova A., Lindenmeyer M.T., Cohen C.D., Bucala R., Strnad P., Goumenos D.S., Floege J., Boor P. (2016): Keratins as Novel Markers of Renal Epithelial Cell Injury. Kidney International, 89 (4), 792-808, [7.683]
• Celec P. , Tóthová L., Šebeková L., Podracká L., Boor P. (2016): Salivary markers of kidney function - potentials and limitations. Clinica Chimica Acta, 453, 28-37, [2.799]
• Braun, G. S. , Nagayama, Y., Maruta, Y., Heymann, F., van Roeyen, C. R., Klinkhammer, B. M., Boor, P., Villa, L., Salant, D. J., Raffetseder, U., Rose-John, S., Ostendorf, T., Floege, J. (2016): Interleukin-6 trans-signaling drives murine crescentic glomerulonephritis.. Journal of the American Society of Nephrology, 27 (1), 132-142, [8.491]
• Boor P. (2016): Albuminuria — a marker of systemic microvascular function. Nature Reviews Nephrology, 12(8), 449-50, [9.463]
• Buhl, E. M. , Djudjaj, S., Babickova, J., Klinkhammer, B. M., Folestad, E., Borkham-Kamphorst, E., Weiskirchen, R., Hudkins, K., Alpers, C. E., Eriksson, U., Floege, J., Boor, P. (2016): Role of PDGF-D in healthy and fibrotic kidneys.. Kidney Int, 89, 848-861, [7.683]
• Kuppe, C. , Gröne, H. J., Ostendorf, T., van Kuppevelt, T. H., Boor, P., Floege, J., Smeets, B., Moeller, M. J. (2015): Common histological patterns in glomerular epithelial cells in secondary focal segmental glomerulosclerosis.. Kidney Intdoi, 10.1038, ki.2015.116, [7.683]
• Görtz, D. (2015): Anti-interleukin-6 therapy through application of a monogenic protein inhibitor via gene delivery. Sci Rep, [5.580]
• Toivola, D. M. , Boor, P., Alam, C., Strnad, P. (2015): Keratins in health and disease.. Current Opinion in Cell Biology, 32, 73-81, [8.851]
• Schierwagen, R. , Maybüchen, L., Zimmer, S., Hittatiya, K., Bäck, C., Klein, S., Uschner, F. E., Reul, W., Boor, P., Nickenig, G., Strassburg, C. P., Trautwein, C., Plat, J., Lütjohann, D., Sauerbruch, J. (2015): Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis. Sci Rep, Aug 11;5, 12931, [5.580]
• Papasotiriou, M. , Genovese, F., Klinkhammer, B. M., Kunter, U., Nielsen, S. H., Karsdal, M. A., Floege, J., Boor, P. (2015): Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases.. Nephrol Dial Transplant, 30, 1112-1121, [4.085]
• Kalenski, J. , ., Mancina, E., Paschenda, P., Beckers, C., Bleilevens, C., Tóthová, L'., Boor, P., Doorschodt, B. M., Tolba, R.H. (2015): Improved Preservation of Warm Ischemia Damaged Porcine Kidneys after Cold Storage in Ecosol, a Novel Preservation Solution.. Annals of Transplantation, 20, 233-242, [1.032]
• Genovese, F. , Boor, Ü., Üaüasotiriou, M., Leeming, D. J., Karsdal, M. A., Floege, J. (2015): Turnover of type III collagen reflects disease severity and is associated with progression and microinflammation in patients with IgA nephropathy.. Nephrol Dial Transplant, pii, gfv, 301, [3.580]
• Engel, D. R. , Krause, T., Snelgrove, S., Thiebes, S., Boor, P., Kitching, R., Kurts, C. (2015): (2015): CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages.. J Immunol, 194, 1628-1638, [4.920]
• Djudjaj, S , Lue, H. J., Rong, S., Papasotiriou, M., Klinkhammer, B. M., Zok, S., Klaener, O., Braun, G. S., Lindenmeyer, M. T., Cohen, C. D., Bucala, R., Tittel, A. P., Kurts, C., Moeller, M. J., Floege, J., Boor, P. (2015): Macrophage migration inhibitory factor mediates proliferative glomerulonephritis via CD74.. J Am Soc Nephrol, , in press, [9.340]
• Boor, P. , Bábíčková, J., Steegh, F., Hautvast, P., Martin, I. V., Djudjaj, S., Nakagawa, T., Ehling, J., Gremse, F., Bücher, E., Eriksson, U., van Roeyen, C. R. C., Eitner, F., Lammers, T., Floege, T. (2015): Role of PDGF-CC in capillary rarefaction in renal fibrosis.. Am J Pathol, 185, 2132-2142, [4.590]
• Boor, P. , Papasptiriou, M. E. (2015): If you lose your nerves, at least you will not get kidney fibrosis!. Kidney Int, 87(2), 275-277, [8.560]
• Boor, P , Perkuhn, M., Weibrecht, M., Zok, S., Martin, I. V., Gieseke, J., Schoth, F., Ostendorf, T., Kuhl, C., Floege, J. (2015): Diffusion-weighted MR imaging does not reflect kidney fibrosis in rat model of fibrosis.. JMRI, 1002/jmri, 24853, [2.510]
• Nagayama, Y. (2014): Gp130-dependent signaling in the podocyte.. American Journal of Physiology Renal Physiology, 307 (3), F346-F355, [3.390]
• Kim, S. , Becker, J., Bechheim, M., Kaiser, V., Noursadeghi, M., Fricker, N., Beier, E., Klaschik, S., Boor, P., Hess, T., Hofmann, A., Holdenrieder, S., Wendland, J., Fröhlich, H., Hartmann, G., Nöthen, M., Müller-Myhsok, B., Pütz, B., Hornung, V., Schumacher, J. (2014): Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes. Nature Communications, 5, 5236, [11.329]
• Alidousty, C. , Rauen, T., Hanssen, L., Wang, Q., Alampour-Rajabi, S., Mertens, P.R., Bernhagen, J., Floege, J., Ostendorf, T., Raffetseder, U. (2014): Calcineurin-mediated YB-1 dephosphorylation regulates CCL5 expression during monocyte differentiation.. Journal of Biological Chemistry, [4.258]
• Berger, K. , Bangen, J. M., Hammerich, L., Liedtke, C., Floege, J., Smeets, B., Moeller, M. J. (2014): Origin of regenerating tubular cells after acute kidney injury.. Proc Natl Acad Sci U S A, 111(4), 1533-1538, [9.423]
• Wögenstein, K. L. , Szabo, S., Lunova, M., Wiche, G., Haybaeck, J., Strnad, P., Boor, P., Wagner, M., Fuchs, P. (2014): Epiplakin-deficiecy aggravates caerulein-induced murine pancreatitis by impaired acinar keratin filament reorganization. PLoS One, 18 (9), e108323, [3.057]
• Smeets, B. , Stucker, F., Wetzels, J., Brocherigou, I., Ronco, P., Gröne, H. J., D'Agati, V., Fogo, A., van Kuppevelt, T. H., Fischer, H. P., Boor, P., Floege, J., Ostendorf, T., Moeller, M. J. (2014): Detection of activated parietal epithelial cells on the glomerular tuft distinguishes early focal segmental glomerulosclerosis from minimal change disease. The American Journal of Pathology, 184, 3240-3248, [4.206]
• Schulte, K. , Berger, K., Boor, P., Jirak, P., Gelman, I. H., Arkull, K. P., Neal, C. R., Kriz, W., Floege, J., Smeets, B., Moeller, M. J. (2014): Origin of Parietal Podocytes in Atubular Glomeruli Mapped by Lineage Tracing. Journal of the American Society of Nephrology, 25(1), 129-141, [8.491]
• Ostendorf, T. , Boor, P., van Roeyen, C. R. C., Floege, J. (2014): Platelet Derived Growth Factors (PDGFs) in Glomerular and Tubulointerstitial Fibrosis.. Kidney International Supplements, 4, 65-69, [7.026]
• Genovese, F. , Manresa, A. A., Leeming, D. J., Karsdal, M. A., Boor, P. (2014): The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?. Fibrogenesis &Tissue Repair, 7(1), 4, [2.329]
• Boor, P. , Ostendorf, T., Floege, J. (2014): PDGF and the progression of renal disease. Nephrology Dialysis Transplantation, 29, 45-54, [4.085]
• Berger, K. , Schulte, K., Boor, P., Kuppe, C., van Kuppevelt, T. H., Floege, J., Smeets, B., Moeller, M. J. (2014): The Regenerative Potential of Parietal Epithelial Cells in Adult Mice.. J Am Soc Nephrol., 25(4), 693-705, [8.491]
• Klinkhammer, B. M. , Kramann R., Mallau M., Makowska A., van Roeyen C.R., Rong S., Buecher E.B.. Boor P., Kovacova K., Zok S., Denecke B., Stuettgen E., Otten S., Floege J., Kunter U. (2014): Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential. PLoS One, 9 (3), e92-115, [3.057]
• Hanssen, L. , Alidoutsy, C., Djudjaj, S., Frye, B.C., Rauen, T., Boor, Pr., Mertens, P.R., van Roeyen, C.R., Tacke, F., Heymann, F., Tittel, A.P., Koch, A., Floege, J., Ostendorf, T., Raffetseder, U. (2013): YB-1 is an early and central mediator of bacterial and sterile inflammation in vivo.. The Journal of Immunology, 191(5), 2604-2613, [4.179]
• Villa, L. , Boor P, Konieczny A, Kunter U, van Roeyen CRC, Denecke B, Gan L, Neusser MA and Cohen CD for the ERCB-Consortium, Eitner F, Scholl T, Ostendorf T, Floege J (2013): Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms. The Journal of Pathology, 229 (5), 672-84, [7.430]
• Seikrit, C. , Henkel C, van Roeyen CRC, Bokemeyer D, Eitner F, Martin IV, Boor P, Ruth Knüchel, Meyer HE, Müller-Newen G, Eriksson U, Floege J, Ostendorf T. (2013): Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts. Nephrol Dial Transplant, Apr;28(4), 889-900, [4.085]
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