P28 PD Dr. Strnad
Akkumulation von Eisen und α1-antitrypsin als hepatozelluläre Initiatoren der Leberfibrose

Wir wollen die Rolle von Eisenüberladung und α1-antitrypsin (AAT)-Mutation als human-relevante Leberfibrose-Initiatoren analysieren. Die Bedeutung der lysosomalen Dysfunktion wird in Hepcidin-Knockouts (KOs, Modell der Eisenüberladung) und AAT-mutierten Tieren untersucht, die mit p62 oder CHOP KOs verpaart wurden. Tierexperimente werden durch Evaluation der AAT Patienten vervollständigt, um die Mechanismen der Krankheitsentwicklung sowie die Rolle von modifizierenden Faktoren wie Übergewicht oder Alkoholkonsum zu adressieren. [...]

Publikationen

• Alsamman, M. , Sterzer, V., Meurer, S. K., Sahin, H., Schaeper, U., Kuscuoglu, D., Strnad, P., Weiskirchen, R., Trautwein, C., Scholten, D. (2018): Endoglin in human liver disease and murine models of liver fibrosis – a protective factor against liver fibrosis. Liver International, 38, 858-867, [4.470]
• Strnad, P. , Tacke, F., Koch, A., Trautwein (2017): Liver - guardian, modifier and target of sepsis. Nature Reviews Gastroenterology & Hepatology, 14(1), 55-66, [14.435]
• Bruns, T. , Nuraldeen, R., Mai, M., Stengel, S., Zimmermann, H., Yagmur, E., Trautwein, C., Stallmach, A., Strnad, P. (2017): Low serum transferrin correlates with acute-on-chronic organ failure and indicates short-term mortality in decompensated cirrhosis. Wiley Liver International, 37 (2), 232–241, [4.470]
• Lunova, M. , Schwarz, P., Nuraldeen, R., Levada, K., Kuscuoglu, D., Stützle, M., Vuji´c Spasi´c, M., Haybaeck, J., Ruchala, P., Jirsa, M., Deschemin, J.-C., Vaulont, S., Trautwein, C., Strnad, P. (2017): Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells. Journal of Pathology, 241(1), 104–114, [7.381]
• Guldiken N. , Ensari G.K., Lahiri P., Couchy G., Preisinger C., Liedtke C., Zimmermann H.W., Ziol M., Boor P., Zucman-Rossi J., Trautwein C., Strnad P. (2016): Keratin 23 is a general stress-inducible marker of mouse and human ductular reaction in liver disease. Journal of Hepatology, 65(3), 552–559, [10.590]
• Djudjaj S. , Papasotiriou M., Bülow R.D., Wagnerova A., Lindenmeyer M.T., Cohen C.D., Bucala R., Strnad P., Goumenos D.S., Floege J., Boor P. (2016): Keratins as Novel Markers of Renal Epithelial Cell Injury. Kidney International, 89 (4), 792-808, [7.683]
• Usachov, V. , Urban, T. J., Fontana, R. J., Gross, A., Iyer, S., Omary, M. B., Strnad, P. (2015): Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury.. BMC Medicine, 13, 196, [2.726]
• Wallace, M. C., , Hamesch, K., Lunova, M., Kim, Y., Weiskirchen, R., Strnad, P., Friedman, S. L. (2015): Standard Operating Procedures in experimental liver research: Thioacetamide model in mice. Laboratory Animals, 49(1), 59-69, [1.120]
• Szabo, S. , Wögenstein, K. L., Österreicher, C. H., Guldiken, N., Chen, Y., Doler, C., Wiche, G., Haybaeck, J., Strnad, P., Fuchs, P. (2015): Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization.. J Hepatol, 62, 1357-1366, [11.340]
• Toivola, D. M. , Boor, P., Alam, C., Strnad, P. (2015): Keratins in health and disease.. Current Opinion in Cell Biology, 32, 73-81, [8.851]
• Sunami, Y. , Von Figura, G., Kleger, A., Strnad, P., Hüser, N., Hartmann, D. (2015): The Role of Telomeres in Liver Disease. Prog Mol Biol Transl Sci, 125, 159-172,
• Lunova, M. , Trautwein, C., Nahon, P., Strnad, P. (2015): Hepcidin in chronic liver disease and hepatocellular carcinoma: The plot thickens. J Hepatol, 62, 979-980, [10.590]
• Hamesch, K. , Borkham-Kamphorst, E., Strnad, P., Weiskirchen, R. (2015): Lipopolysaccharide-induced inflammatory liver injury in mice.. Lab Anim, 49(S1), 37-46, [1.120]
• Guldiken, N. , Zhou, Q., Kucukoglu, O., Rehm, M., Levada, K., Gross, A., Kwan, R., James, L. P., Trautwein, C., Omary, M. B., Strnad, P. (2015): Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with JNK activation and protein adduct formation.. Hepatology, , in press, [11.050]
• Guldiken, N. , Usachov, V., Levada, K., Trautwein, C., Ziol, M., Nahon, P., Strnad, P. (2015): Keratins 8 and 18 are type II acute-phase responsive genes overexpressed in human liver disease.. Liver Int, 35, 1203-1212, [4.850]
• Wögenstein, K. L. , Szabo, S., Lunova, M., Wiche, G., Haybaeck, J., Strnad, P., Boor, P., Wagner, M., Fuchs, P. (2014): Epiplakin-deficiecy aggravates caerulein-induced murine pancreatitis by impaired acinar keratin filament reorganization. PLoS One, 18 (9), e108323, [3.057]
• Strnad, P. , Nuraldeen, R., Guldiken, N., Hartmann, D., Mahajan, V., Denk, H., Haybaeck, J. (2014): Broad Spectrum of Hepatocyte Inclusions in Humans, Animals, and Experimental Models. Comprehensive Physiology, 3 (4), 1393-1436, [6.364]
• Lunova, M. , Goehring, C., Mueller, K., Chen, Y., Walther, P., Vaulont, S., Haybaeck, J., Lackner, C., Trautwein, C., Strnad, P. (2014): Hepcidin knockout mice fed with iron-rich diet develop chronic liver injury and liver fibrosis due to lysosomal iron overload.. Journal of Hepatology, 61 (3), 633-641, [10.590]
• Kucukoglu, O. , Guldiken, N., Chen, Y., Usachov, V., Elheliebi, A., Haybaeck, J., Denk, H. W., Trautwein, C., Strnad, P. (2014): High-fat diet triggers Mallory-Denk body formation via misfolding and crosslinking of excess keratin 8.. Hepatology, 60 (1), 169-178, [11.711]
• Strnad, P. , Von Figura, G., Gruss, R., Jareis, K. M., Stiehl, A., Kulaksiz, H. (2013): Oblique Bile Duct Predisposes to the Recurrence of Bile Duct Stones. Plos One, 8(1), [3.057]
• Mueller, K. , Sunami, Y., Stuetzle, M., Güldiken, N., Kucukoglu, O., Mueller, S., Kulaksiz, H. W., Schwarz, P., Strnad, P. (2013): CHOP-mediated hepcidin suppression modulates hepatic iron load. The Journal of Pathology, 231 (4), 532-542, [7.381]